The effect of endometrial injury on first cycle IVF/ICSI outcome: A randomized controlled trial
نویسندگان
چکیده
BACKGROUND Implantation remains a limiting step in IVF/ICSI. Endometrial injury isa promising procedure aiming at improving the implantation and pregnancy rates after IVF/ICSI. OBJECTIVE The aim of this study was to evaluate the effect of endometrial injury induced in precedingcycle on IVF/ICSI outcome. MATERIALS AND METHODS Four hundred patients undergoing their first IVF/ICSI cycle in two IVF units in Minia, Egypt were randomly selected to undergo either endometrial injury in luteal phase of preceding cycle (intervention group) or no treatment (control group). Primary outcome wasthe implantation and live birth ratesWhile the secondary outcome was clinical pregnancy, miscarriage, multiple pregnancy rates, pain and bleeding during and after procedure. RESULTS Implantation and live birth rates were significantly higher in intervention compared with control group (22.4% vs. 18.7%, p=0.02 and 67% vs. 28%, p=0.03), respectively. There was also a significant reduction in miscarriage rate in intervention group (4.8% vs. 19.7%, respectively, p<0.001). CONCLUSION Endometrial injury in preceding cycle improves the implantation rate and live birth rate and reduces the miscarriage rate per clinical pregnancy in patients undergoing their first IVF/ICSI cycle.
منابع مشابه
The Effect of Vaginal Sildenafil on The Outcome of Assisted Reproductive Technology Cycles in Patients with Repeated Implantation Failures: A Randomized Placebo-Controlled Trial
Objective Objective: The aim of this study was to investigate the effects of vaginal sildenafil on the outcome of patients with at least two times of unsuccessful IVF / ICSI. MaterialsAndMethods Method and Material(s): A total of 66 infertile women aged ≤ 38 years, with a history of normal ovarian reserve, two prior consecutive failed IVF/ICSI attempts, hCG day endometrial thickness
متن کاملP-228: Low Dose HCG Adjunct to r-hFSH/GnRH Antagonist for Controlled Ovarian Stimulation in Assisted Reproductive Technology: A Prospective and Randomized Trial
Background: Deep suppression of LH in GnRH antagonist cycles may have detrimental effect on reproductive out come. It was hypnotized that adding LH activity via the administration of low dose HCG in late follicular phase shortened the duration of stimulation, decreased consumption of gonadotropin and increased estrogen levels. This study was designed to evaluate the effect of adding low dose HC...
متن کاملEndometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342)
BACKGROUND Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is t...
متن کاملEfficacy of the local endometrial injury in patients who had previous failed IVF-ICSI outcome
BACKGROUND The latest studies reported that local endometrial injury is a useful method to improve the success of IVF-ICSI outcome. OBJECTIVE To assess whether local endometrial injury occurred by Pipelle in the spontaneous cycle could improve implantation rate, cleavage rate, and pregnancy outcome in the subsequent IVF-ICSI cycle in patients who had recurrent IVF failure. MATERIALS AND MET...
متن کاملDoes low-dose aspirin improve pregnancy rate in IVF/ICSI? A randomized double-blind placebo controlled trial.
BACKGROUND It has been suggested in the literature that low-dose aspirin leads to an increased number of oocytes in IVF/ICSI as well as a higher pregnancy rate. The aim of the present study was to investigate the effect of daily administration of low-dose aspirin, compared with placebo, on pregnancy rate in IVF and ICSI. METHODS This study was a prospective, randomized, double-blind placebo c...
متن کامل